Web supplement to
"Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action"

Maureen E. Hillenmeyer, Elke Ericson, Ronald W. Davis, Corey Nislow, Daphne Koller, Guri Giaever

Hillenmeyer 2010 psychoactive drug cluster

Abstract

We systematically analyzed the relationships between gene fitness profiles (co-fitness) and drug inhibition profiles (co-inhibition) from several hundred chemogenomic screens in yeast. Co-fitness predicted gene functions distinct from those derived from other assays and identified conditionally-sensitive protein complexes. Co-inhibitory compounds were weakly correlated by structure and therapeutic class. We developed an algorithm predicting protein targets of chemical compounds and verified its accuracy with experimental testing. Fitness data provide a novel, systems-level perspective on the cell.

Interactive website: FitDB

For a graphical interface to the chemogenomic fitness data, visit FitDB or type a query in the box on the left.





Inquiries can be addressed to guri.giaever@utoronto.ca.