Selected Publications

Hillenmeyer, M.E. Fung, E. Wildenhain, J. Pierce, S.E. Hoon, S. Lee, W. Proctor, M. St.Onge, R.P. Tyers, M. Koller, D. Altman, R.B. Davis, R.W. Nislow, C. Giaever G. The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes. Science 18 April 2008: Vol. 320. no. 5874, pp. 362 - 365 [Web supplement]

Nislow C. and Giaever G. Chemical Genomic Tools for Understanding Gene Function and Drug Action. Methods in Microbiology (in press).

Gassner N.C., Tamble C.M., Bock J.E., Cotton N., White K.N., Tenney K., St Onge R.P., Proctor M.J., Giaever G., Nislow C., Davis R.W., Crews P., Holman T.R., Lokey R.S. Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay. J Nat Prod 70(3):383-90 (2007). [PubMed]

St.Onge, R.P., Mani, R., Oh, J., Proctor, M, Fung, E., Davis, R.W., Nislow, C., Roth, F.P., Giaever, G. Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nat Genet 39(2): 199-206 (2007) (Subject of Highlight in Nat Rev Genet 8: 87 (2007). [Publisher Full Text]

Juneau K, Miranda M, Hillenmeyer ME, Nislow C, Davis RW. Introns regulate RNA and protein abundance in yeast. Genetics. 2006 Sep;174(1):511-8. Epub 2006 Jul 2. [PubMed]

Pierce, SE, Fung, EL, Jaramillo, DF, Chu AM, Davis, RW, Nislow, C., Giaever, G. A unique and universal molecular barcode array.Nat Methods, 2006 Aug;3(8):601-3. [PubMed]

Lee, W., St.Onge, R.P., Proctor, M., Flaherty, P., Jordan, M.I., Arkin, A.P., Davis, R.W., Nislow, C. Giaever, G. Genome-Wide Requirements for Resistance to Functionally Distinct DNA-Damaging Agents. PLoS Genet. 2005 Aug 19;1(2):e24 [Epub][PubMed], [Web supplement]

Flaherty, P., Giaever, G. Kumm, J., Jordan, M.I., Arkin, A.P. A latent variable model for chemogenomic profiling. Bioinformatics. 2005 Aug 1;21(15):3286-93. Epub 2005 May 26. [PubMed], [Publisher Full Text]

Wall, D.P., Hirsh, A.E., Fraser, H.B., Kumm, J., Giaever, G., Eisen, M.B., Feldman, M.V. Functional genomic analysis of the rates of protein evolution. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5483-8. Epub 2005 Mar 30. [PubMed], [Publisher Full Text]

Deutschbauer, A.M., Jaramillo, D.F., Proctor, M., Kumm, J., Hillenmeyer, M.E., Davis, R.W., Giaever, G. Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics. 2005 Apr;169(4):1915-25. Epub 2005 Feb 16. [Web supplement], [Epub]

Fraser, H.B., Hirsh, A.E , Giaever, G , Kumm, J. and Eisen, M. Noise Minimization in Eukaryotic Gene Expression. PLOS Biology 2(6):E137. Epub Apr 27 (2004). [Publisher Full Text]

Giaever, G., Flaherty P., Kumm J., Proctor M., Nislow C., Jaramillo D.F., Chu A.M., Jordan M.I., Arkin A.P., Davis R.W. Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc Natl Acad Sci 101(22):793-8 (2004). Subject of review: Hughes T., Andrews B., Boone C.  Old drugs, new tricks: using genetically sensitized yeast to reveal drug targets.  Cell 116(1):5-7 (2004). [Publisher Full Text]

Giaever, G. A chemical genomics approach to understanding drug action. Trends Pharmacol Sci. 24(9):444-6 (2003). [PubMed]

Nislow, C. and Giaever, G. "Chemogenomics: tools for protein families" and "Chemical genomics: chemical and biological integration" Pharmacogenomics. Jan;4(1):15-8 (2003). [PubMed]

Giaever, G., Chu, A.M., Ni, L. et al. Functional profiling of the Saccharomyces cerevisiae genome.  Nature 418(6896):387-91 (2002). [Web supplement]

Steinmetz L.M., Scharfe C., Deutschbauer A.M., Mokranjac D., Herman Z.S., Jones T., Chu A.M., Giaever G., Prokisch H., Oefner P.J., Davis R.W. Systematic screen for human disease genes in yeast. Nat Genet. 31(4):400-4 (2002). [PubMed]

Birrell G.W., Brown J.A., Wu H.I., Giaever G., Chu A.M., Davis R.W., Brown J.M. Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents. Proc Natl Acad Sci 99(13):8778-83 (2002). [Publisher Full Text]

Birell, G.W., Giaever, G., Chu, A., Davis, R.W. and Brown, J.M.  A genome-wide screen in Sacharromyces cerevisiae for genes affecting UV radiation sensitivity. Proc. Natl. Acad. Sci. 98 (22): 12608-12613 (2001). [Publisher Full Text]

Giaever, G., Shoemaker, D.D, Jones, T.W., Liang, H., Winzeler, E. Astromoff, A. and Davis, R.W. Genomic profiling of drug sensitivities via induced haploinsufficiency.  Nature Genetics 21: 278-283 (1999) (Subject of News & Views by Stephen Oliver, same issue). [PubMed]

Winzeler, E. et al. Functional characterization of the Saccharomyces cerevisiae genome by comprehensive and precise gene deletion and massively parallel analysis. Science 285: 901-906 (1999).